SNIPER(ABL)-020

SKU: orb1987743

Description

SNIPER(ABL)-020 is a conjugate of the ABL inhibitor Dasatinib and the IAP ligand Bestatin, linked to effectively degrade BCR-ABL. This proteolysis-targeting chimera (PROTAC) has demonstrated utility in both in vitro and in vivo research models for studying chronic myeloid leukemia (CML) and drug resistance mechanisms.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 923.52
• Formula: C₄₄H₅₉ClN₁₀O₈S
• SMILES: CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC5=CC=CC=C5)N)=O)=O)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
• Target: Others,Bcr-Abl,SNIPERs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377570