SN32976

SKU: orb1297875

Description

SN32976 is a pan-PI3K inhibitor with potent activity against PI3K isoforms and mTOR, showing a preference for PI3Kα over PI3Kδ. It is a valuable research tool for studying PI3K signaling in cancer biology and has been utilized in both in vitro cellular assays and in vivo tumor model studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1246202-11-8
• MW: 581.64
• Purity: 98.88%
• Formula: C₂₄H₃₃F₂N₉O₄S
• SMILES: C(F)(F)C=1N(C=2C(N1)=C(OC)C=CC2)C=3N=C(N=C(N3)N4CCOCC4)N5CCN(S(CCN(C)C)(=O)=O)CC5
• Target: mTOR,PI3K
• Solubility: DMSO:5.82 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  PI3Kα:15.1 nM|PI3Kβ:461 nM|mTOR:194 nM|PI3Kγ:110 nM|PI3Kδ:134 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3K, PI3Kα, PI3Kδ, SN 32976, SN32976, SN-32976

Compound Identifiers

PubChem CID

46917573