Smurf1-IN-5

SKU: orb3135646

Description

Smurf1-IN-5 (Compound cpd-6) is an inhibitor of the SMAD ubiquitin regulatory factor (SMURF1). It reduces the ubiquitination of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, thereby enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 holds promise for research in pulmonary arterial hypertension (PAH).

Research Area

Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1824647-09-7
• MW: 480.92
• Formula: C₂₅H₂₂ClFN₄O₃
• SMILES: O=C(NC=1C(=O)N(C=2C=CC=CC2F)N(C1C)C)C3=NOC(C=4C=CC(=CC4Cl)C5CC5)=C3C
• Target: E1/E2/E3 Enzyme

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

E1/E2/E3 Enzyme