SMS1-IN-1

SKU: orb1309084

Description

SMS1-IN-1 is a potent and selective inhibitor of sphingomyelin synthase 1 (SMS1) with an IC50 of 2.1 µM. This compound serves as a valuable research tool for investigating the role of SMS1 in lipid metabolism, particularly in atherosclerosis studies using both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1807943-38-9
• MW: 503.41
• Purity: 99.59% (May vary between batches)
• Formula: C₂₃H₂₃BrN₂O₄S
• SMILES: Brc1ccc(CNC(=O)COc2ccc(cc2)S(=O)(=O)NCCc2ccccc2)cc1
• Target: Others
• Solubility: DMSO:245 mg/mL (486.68 mM)

Bioactivity

• Target IC50:
  SMS1:2.1 μM
• In Vitro:
  SMS1-IN-1 (2.5, 10 and 50 μM) shows inhibitory effect against SMS1 in a dose-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, atherosclerosis, SM biosynthetic, SMS1, SMS1 IN 1, SMS1IN1, SMS-1-IN-1, SMS1-IN-1

Compound Identifiers

PubChem CID

91938094