SMO-IN-2

SKU: orb1686614

Description

SMO-IN-2 is a potent and selective smoothened (SMO) antagonist that inhibits the Hedgehog signaling pathway. It demonstrates antiproliferative and anticancer effects in human medulloblastoma cell lines in vitro and has been utilized in various in vivo cancer research models to study tumor growth and pathway inhibition.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1822355-27-0
• MW: 503.49
• Purity: 98.76% (May vary between batches)
• Formula: C₂₅H₂₅F₄N₅O₂
• SMILES: N(C1=C(C(=O)N2CCC(N(C(=O)C3=C(C(F)(F)F)C=C(F)C=C3)C)CC2)C=CC=C1)C=4N(C)N=CC4
• Target: Smo,Hedgehog/Smoothened
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.99 mM);DMSO:7.14 mg/mL (14.18 mM)

Bioactivity

• Target IC50:
  Daoy cells:0.51 μM
• In Vitro:
  Compound 1, also known as SMO-IN-2, exhibits antiproliferative activity against the human medulloblastoma cell line Daoy, with an IC50 of 0.51 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hedgehog, Smoothened

Compound Identifiers

PubChem CID

147359459