SMI-16a

SKU: orb1303469

Description

SMI-16a is a potent and selective ATP-competitive inhibitor of Pim-1 and Pim-2 kinases, with IC50 values of 150 nM and 20 nM, respectively. It demonstrates high selectivity, showing minimal activity against 57 other kinases. This compound is a valuable chemical probe for investigating Pim kinase function in cancer research and cellular signaling studies both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 587852-28-6
• MW: 263.31
• Purity: 99.99% (May vary between batches)
• Formula: C₁₃H₁₃NO₃S
• SMILES: CCCOc1ccc(\C=C2\SC(=O)NC2=O)cc1
• Target: Pim
• Solubility: DMSO:150 mg/mL (569.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.19 mM)

Bioactivity

• Target IC50:
  Pim1:150 nM|Pim2:20 nM
• In Vivo:
  PIM1/2 Kinase Inhibitor VI exhibits antitumor activity in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg/day, i.p.).
• In Vitro:
  PIM1/2 Kinase Inhibitor VI exhibits antitumor activity in PC3 human prostate cancer cultures in vitro (IC50: 48 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, SMI16a, SMI-16a, SMI 16a, Pim2, PIM1/2 Kinase Inhibitor VI, Pim, Pim kinases, Pim1

Compound Identifiers

PubChem CID

25102785