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SMI-10B13

SKU: orb3136837

Description

SMI-10B13 is an inhibitor of oncostatin M (OSM) with a dissociation constant (KD) of 6.6 μM. It effectively inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines, with IC50 values of 136 nM and 164 nM, respectively. SMI-10B13 demonstrates antitumor activity in a human breast cancer mouse model.

Research Area

Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2502294-68-8
MW368.39
FormulaC23H16N2O3
SMILESO=C(O)C=CC=1OC(C=2C=CC=3C=CNC3C2)=C(C1)C=4C=CC=5C=CNC5C4
TargetInterleukin,STAT

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information