SMER3

SKU: orb1305650

Description

SMER3 is a cell-permeable small molecule inhibitor of the SCF(Met30) E3 ubiquitin ligase. It is a valuable research tool for studying ubiquitin-mediated proteolysis in processes such as cell cycle regulation, transcription, and immune signaling in both cellular and biochemical assays.

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 67200-34-4
• MW: 224.18
• Purity: 98.35% (May vary between batches)
• Formula: C₁₁H₄N₄O₂
• SMILES: O=C1c2ccccc2-c2nc3nonc3nc12
• Target: E1/E2/E3 Enzyme,Ligands for E3 Ligase
• Solubility: DMSO:8 mg/mL (35.69 mM)

Bioactivity

• In Vivo:
  SMER 3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and show evidence for SMER 3 directly binding to Met30.
• In Vitro:
  SMER 3 and rapidly increased PFKFB3 protein levels. Accordingly, ubiquitin-bound PFKFB3 was lower in E2- or G1-treated HUVECs. Both agents increased deubiquitinase USP19 levels through GPER signaling.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anticancer, E3 ligating enzyme, E2 conjugating enzyme, E1/E2/E3 Enzyme, E3 Ligase, E1 activating enzyme, Cullin, Inhibitor, inhibit, ligase, LigandforE3Ligase, Ligand for E3 Ligase, MET, SCF, Skp1, SMER 3, SMER3, SMER-3, Ubiquitin activating enzyme, ubiquitin, Ubiquitin conjugating enzyme, Ubiquitin ligase

Compound Identifiers

PubChem CID

568763