SMER18

SKU: orb1706620

Description

SMER18 is a small molecule autophagy inducer that functions independently of mTOR, thereby enhancing the effects of rapamycin. It serves as a valuable research tool for investigating autophagy mechanisms and their implications in neurodegenerative disease models, both in vitro and in vivo.

Research Area

Cell Biology

Key Properties

• CAS Number: 944153-47-3
• MW: 287.74
• Purity: 97.27%
• Formula: C₁₆H₁₄ClNO₂
• SMILES: C\C(Nc1cccc(O)c1)=C\C(=O)c1ccc(Cl)cc1
• Target: Autophagy
• Solubility: DMSO:80 mg/mL (278.03 mM)

Bioactivity

• In Vitro:
  SMER18 is a small molecule enhancer of rapamycin that functions as an mTOR-independent autophagy inducer, capable of enhancing the clearance of autophagy substrates such as mutant htt (related to Huntington's disease) and A53T α-synuclein (associated with familial Parkinson's disease).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, SMER 18, SMER18, SMER-18

Compound Identifiers

PubChem CID

877863