SMD-3040

SKU: orb2277652

Description

SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), comprising an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellent degradation selectivity for the SMARCA2 protein over the SMARCA4 protein and has demonstrated robust tumor growth inhibition in xenograft models.

Key Properties

• CAS Number: 3033109-92-8
• MW: 943.21
• Formula: C₅₂H₆₆N₁₀O₅S
• SMILES: CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC([C@@H]4CC[C@@H](CN5CC6(CCC(N7C=C(C8=CC(C9=CC=CC=C9O)=NN=C8N)C=N7)CC6)C5)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1
• Target: PROTACs,Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,Epigenetic Reader Domain