SMD-3040

SKU: orb2277652

Description

SMD-3040 is a potent and selective SMARCA2 PROTAC degrader with a DC50 of 12 nM. It achieves robust SMARCA2 degradation over SMARCA4 and has demonstrated significant tumor growth inhibition in xenograft models, supporting its use in oncology and targeted protein degradation research.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3033109-92-8
• MW: 943.21
• Formula: C₅₂H₆₆N₁₀O₅S
• SMILES: C(N1CC2(C1)CCC(CC2)N3C=C(C=N3)C=4C=C(N=NC4N)C5=C(O)C=CC=C5)[C@H]6CC[C@H](C(N[C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)(C)C)=O)CC6
• Target: PROTACs,Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168433318