SMARCA2-IN-8

SKU: orb2664485

Description

SMARCA2-IN-8 (Compound 13) is a potent, orally bioavailable dual inhibitor of SMARCA2/BRM and SMARCA4/BRG1 with low nM IC50 values. It suppresses proliferation and target gene expression in SMARCA2-mutant cancer cells in vitro and demonstrates in vivo antitumor efficacy in mouse models, supporting its use in oncology research targeting SWI/SNF chromatin remodelers.

Research Area

Neuroscience

Key Properties

• CAS Number: 2270875-93-7
• MW: 303.26
• Formula: C₁₀H₈F₃N₅OS
• SMILES: O=C(NC=1SN=C(C1)C(F)F)NC2=CC(F)=NC=C2N

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145981360