SMARCA2 degrader-17

SKU: orb2663586

Description

SMARCA2 degrader-17 is a small molecule that selectively degrades the SMARCA2 protein. It demonstrates synergistic anti-proliferative activity with Adagrasib in vitro and has shown efficacy in inhibiting tumor growth in vivo, making it a valuable tool for oncology research targeting SWI/SNF chromatin remodeling complexes.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2755761-78-3
• MW: 891.09
• Formula: C₄₇H₅₈N₁₀O₆S
• SMILES: OC1=C(C=2C=C3N4[C@](CN(CC4)[C@H]5CN(C[C@@H](OC=6C=C([C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)[C@@H](C)C)ON6)C)CC5)(CNC3=NN2)[H])C=CC=C1
• Target: Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168152471