PROTAC SMARCA2/4-degrader-17

SKU: orb2664181

Description

PROTAC SMARCA2/4-degrader-17 (I-345) is a potent, cell-permeable small molecule that selectively degrades the SMARCA2 and SMARCA4 bromodomain proteins via the ubiquitin-proteasome system. With DC50 values below 100 nM in cellular assays, it is a valuable chemical probe for studying SWI/SNF complex function in cancer biology and targeted protein degradation research.

Key Properties

• CAS Number: 2568276-88-8
• MW: 936.13
• Formula: C₅₁H₅₇N₁₁O₅S
• SMILES: NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5=C(C)C=C(CC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)C=C5)C=C(N=N1)C9=C(O)C=CC=C9

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

167386748