PROTAC SMARCA2 degrader-17

SKU: orb2665118

Description

PROTAC SMARCA2 degrader-17 (I-290) is a potent and efficient heterobifunctional molecule that selectively degrades the SMARCA2 protein. It demonstrates high degradation potency (DC50 < 100 nM) and achieves over 90% degradation in A549 cells within 24 hours, making it a valuable chemical probe for studying SMARCA2 function in oncology and targeted protein degradation research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2568276-43-5
• MW: 797.95
• Formula: C₄₄H₅₁N₁₁O₄
• SMILES: O=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)C4CCC(N5CCC(C6=CN=C(N=C6)N7C8CN(C=9C=C(N=NC9N)C%10=CC=CC=C%10O)CC7CC8)CC5)CC4)C)CC1
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155405344