SMA-12b

SKU: orb1702792

Description

SMA-12b is a synthetic analog of the parasitic immunomodulator ES-62. It exhibits broad anti-inflammatory and antioxidant transcriptional activity, making it a valuable research tool for studying autoimmune pathologies like rheumatoid arthritis in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1496553-39-9
• MW: 383.29
• Purity: 99.16% (May vary between batches)
• Formula: C₁₃H₂₂INO₂S
• SMILES: [I-].O=S(=O)(CC1=CC=C(C=C1)C)CC[N+](C)(C)C
• Target: Interleukin

Bioactivity

• In Vivo:
  Collagen-induced arthritis (CIA) was induced in male DBA/1 mice (8–10 weeks old) by intradermal immunization with bovine type II collagen in complete Freund's adjuvant and mice were treated with purified endotoxin-free SMA-12b (1 μg/dose) or PBS subcutaneously on days −2, 0 and 21 and scored for development of arthritis as previously described. SMA-12b could also significantly reduce IL-12p40 secretion, it was not as effective with respect to IL-6.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Interleukin Related, SMA 12b, SMA12b, SMA-12b

Compound Identifiers

PubChem CID

73053482