SM1-71

SKU: orb1693536

Description

SM1-71 is a multi-targeted acrylamide-based kinase inhibitor with potent activity against TAK1, MAPKs, SRC, and other key kinases. It functions as a valuable chemical probe in cancer research, demonstrating anti-proliferative effects in various cancer cell lines in vitro.

Research Area

Cardiovascular Research, Cell Biology, Metabolism Research, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2088179-99-9
• MW: 463.96
• Purity: 96.00% (May vary between batches)
• Formula: C₂₄H₂₆ClN₇O
• SMILES: CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3ccccc3NC(=O)C=C)n2)cc1
• Target: TGF-beta/Smad,Src,MAPK,Serine/threonin kinase,AAK1,LIM Kinase,FGFR,S6 Kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.62 mM);DMSO:100 mg/mL (215.54 mM)

Bioactivity

• Target IC50:
  BMP2K:7.1 nM|MAP2K1:10.4 nM|MAP3K1:28.7 nM|GAK:0.8 nM|MAPK3:107 nM|MAP2K2:9.3 nM|AAK1:4.4 nM|YES1:0.8 nM|MAPK1:48.3 nM|LIMK1:5.4 nM|SRC:2 nM
• In Vitro:
  Potently inhibiting the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines in a concentration-dependent manner, SM1-71 (0.001-100 μM; 72 h) demonstrates its efficacy. Additionally, SM1-71 induces potent cytotoxicity within 72 hours, with nanomolar values for GR50 and negative GRmax values observed in eight of 11 cancer cell lines.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AAK1(AP2associatedkinase1), AAK1, AAK1 (AP2 associated kinase 1), AP2associatedkinase1, AP2 associated kinase 1, bone morphogenetic protein (BMP), MAP3K, LIMK1, LIMKinase, LIM Kinase, SM1 71, SM171, SM-1-71, Smad, TAK1, Serine kinase, threoninkinase, threonin kinase, Serinekinase, Serine/threonin kinase, TGF-b/Smad, TGFb, TGFbeta, TGF-beta, TGF-β/Smad, TGFβ, TGFbeta/Smad

Compound Identifiers

PubChem CID

131801160