SM-164 Hydrochloride (957135-43-2 free base)

SKU: orb1708514

Description

SM-164 Hydrochloride is a potent, cell-permeable Smac mimetic that antagonizes XIAP by binding with high affinity (IC50 = 1.39 nM) to its BIR2 and BIR3 domains. It is widely used in cancer research to study apoptosis induction and has demonstrated efficacy in both in vitro cellular assays and in vivo tumor models.

Research Area

Cell Biology

Key Properties

• MW: 1157.88
• Formula: C₆₂H₈₅ClN₁₄O₆
• SMILES: C[C@H](NC)C(N[C@H]1CCCC[C@](CC[C@H]2C(N[C@@H](C3=CC=CC=C3)C4=CN(CCCCC5=CC=C(CCCCN6N=NC([C@@H](NC([C@@H]7CC[C@@](CCCC[C@@H]8NC([C@@H](NC)C)=O)([H])N7C8=O)=O)C9=CC=CC=C9)=C6)C=C5)N=N4)=O)([H])N2C1=O)=O.Cl
• Target: IAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

133053563