SM 16

SKU: orb1302402

Description

SM 16 is a potent and selective small molecule inhibitor of ALK5 and ALK4 kinases, with respective Ki values of 10 nM and 1.5 nM. It is widely used in biochemical and cellular research to investigate TGF-β and activin signaling pathways in fibrosis, cancer, and developmental biology studies.

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 614749-78-9
• MW: 430.5
• Purity: 99.72% (May vary between batches)
• Formula: C₂₅H₂₆N₄O₃
• SMILES: Cc1cccc(n1)-c1[nH]c(nc1-c1ccc2OCOc2c1)C12CCC(CC1)(CC2)C(N)=O
• Target: ALK,TGF-beta/Smad
• Solubility: DMSO:6.25 mg/mL (14.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.32 mM)

Bioactivity

• Target IC50:
  ALK5:10 nM|ALK4:1.5 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Smad, SM16, SM-16, SM 16, TGFbeta, TGF-b/Smad, TGFb, TGF-β/Smad, TGFβ, TGF-β Receptor, TGF-beta, TGFbeta/Smad, Transforming growth factor beta receptors, ALK5, ALK4, inhibit, Inhibitor

Compound Identifiers

PubChem CID

10387982