SLR080811

SKU: orb3175198

Description

SLR080811 is a guanidine-based selective inhibitor of sphingosine kinase 2 (SphK2) with a Ki value of 1.3 μM, demonstrating approximately 10-fold selectivity over SphK1 (Ki = 12 μM). In vitro, it reduces sphingosine-1-phosphate (S1P) levels, but in mice, it can induce SphK1-dependent S1P level increases. SLR080811 is applicable in cancer and fibrosis research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1449765-65-4
• MW: 369.51
• Formula: C₂₁H₃₁N₅O
• SMILES: C(=N)(N)N1[C@H](CCC1)C2=NC(=NO2)C3=CC=C(CCCCCCCC)C=C3
• Target: S1P Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

S1P Receptor