SLP9101555

SKU: orb1686994

Description

SLP9101555 is a potent, selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM, exhibiting over 200-fold selectivity versus SphK1. It effectively lowers extracellular sphingosine-1-phosphate (S1P) levels and is a valuable research tool for studying SphK2 roles in cancer, inflammation, and fibrosis in cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• MW: 471.95
• Purity: 99.45% (May vary between batches)
• Formula: C₂₂H₂₉ClF₃N₅O
• SMILES: FC(F)(F)C1=CC(C2=NOC([C@@H]3CCCN3C(N)=N)=N2)=CC=C1CCC4CCCCC4.Cl
• Target: LPL Receptor,S1P Receptor
• Solubility: DMSO:4.72 mg/mL (10 mM)

Bioactivity

• Target IC50:
  SPHK1:18000 ± 220 nM(Ki)|SPHK2:90 ± 11 nM(Ki)
• In Vivo:
  SLP9101555 (compound 14c) (5 mg/kg; I.P.; single administration) significantly elevates blood S1P levels.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LPL Receptor, LPLReceptor, SphK2, S1P Receptor, S1PR1, S1PReceptor

Compound Identifiers

PubChem CID

56675778