SLD1121

SKU: orb3210423

Description

SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). It interacts with the intracellular domain of LRP6, stabilizing and promoting its nuclear translocation, where it facilitates binding with β-catenin, TCF4, or LEF1, thereby inducing the expression of Wnt-regulated and stem cell-related genes. SLD1121 also stimulates the transition of hair follicles from the resting phase to the growth phase in mice, promoting hair growth, making it useful for research related to hair loss.

Key Properties

• CAS Number: 2759011-75-9
• MW: 415.45
• Formula: C₂₆H₁₇N₅O
• SMILES: O=C(NC=1C=CC=CC1)C=2C=CC(=CC2)C3=NC4=C5C=CC=NC5=C6N=CC=CC6=C4N3
• Target: Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Wnt/beta-catenin