SLC7A11-IN-1

SKU: orb1982551

Description

SLC7A11-IN-1 is a small molecule inhibitor of the cystine/glutamate antiporter SLC7A11, exhibiting anti-proliferative and anti-metastatic activities in vitro. It induces apoptosis and cell cycle arrest, supporting its research application in cancer biology and investigations into ferroptosis-related neurodegenerative disease models.

Research Area

Cell Biology

Key Properties

• CAS Number: 3049302-90-8
• MW: 664.35
• Purity: 95.93%
• Formula: C₁₃H₁₇Cl₂F₃N₄O₅PtS
• SMILES: O=C([O-][Pt+4]([Cl-])([Cl-])([OH-])([NH3])[NH3])CCCC(=O)NC1=NC=2C=CC(OC(F)(F)F)=CC2S1
• Target: Apoptosis
• Solubility: DMSO:16 mg/mL (24.08 mM)

Bioactivity

• Target IC50:
  L02 cells:0.27 µM|HepG2 cells:0.17 µM|MDA-MB-231 cells:0.11 µM|MCF-7 cells:0.18 µM|HCT116 cells:0.03 µM
• In Vivo:
  SLC7A11-IN-1 (2 mg/kg via tail vein injection every three days for three consecutive times) exhibited tumor growth inhibition in mice.
• In Vitro:
  SLC7A11-IN-1 (compound 2) (0-100 µM; 72 hrs of action) exhibited antiproliferative activity against a variety of cell lines with IC50 values of HCT-116: 0.03 µM, MDA-MB-231: 0.11 µM, MCF-7: 0.18 µM, HepG2: 0.17 µM, LO2: 0.27 µM. SLC7A11-IN-1 (0.5 µM, treated for 24 h) inhibited the invasive and migratory abilities of HCT-116 cells, triggered apoptosis, and arrested the cell cycle in S-phase, as well as significantly reduced intracellular GSH levels, while significantly increasing the expression of reactive oxygen species (ROS). SLC7A11-IN-1 (1 µM, 15 hr treatment) significantly induced DNA damage in HCT-116 cells and upregulated the expression of related proteins.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis