SLC13A5-IN-1

SKU: orb1309087

Description

SLC13A5-IN-1 is a potent and selective small molecule inhibitor of the sodium-citrate cotransporter (SLC13A5), demonstrating an IC50 of 22 nM for citrate uptake in HepG2 cells. This compound is a valuable research tool for investigating hepatic metabolism, neuronal excitability, and the role of citrate transport in models of epilepsy and non-alcoholic fatty liver disease (NAFLD).

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2227548-95-8
• MW: 461.79
• Purity: 99.67% (May vary between batches)
• Formula: C₁₉H₁₉Cl₃N₂O₃S
• SMILES: S(=O)(=O)(C1=CC(Cl)=CC(Cl)=C1)N2CCC(C(NCC3=CC=C(Cl)C=C3)=O)CC2
• Target: Stearoyl-CoA Desaturase (SCD),Sodium Channel
• Solubility: DMSO:5 mg/mL (10.83 mM)

Bioactivity

• Target IC50:
  Recombinant hSLC3A5/14C-Citrate Uptake:0.056 μM |HepG2/14C-Citrate uptake:0.022 μM
• In Vitro:
  In HepG2/14C-Citrate Uptake Assay,SLC13A5-IN-1 exhibits an IC50 of 0.022 μM . HepG2 cells endogenously express hSLC13A5 transporter which is responsible for the uptake of citrate into these cells. Uptake of 14C-citrate can be completely blocked by SLC13A5-IN-1 and the signal can be competed with unlabelled citrate.In recombinant hSLC3A5/14C-Citrate Uptake Assay, SLC13A5-IN-1 exhibits an IC50 of 0.056 μM . SLC13A5-IN-1 exhibits an IC50 of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

disease, cardiovascular, Citrate, HepG2/14C-Citrate Uptake Assay, Inhibitor, human HEPG2, hSLC3A5, inhibit, metabolic, Na+ channels, Na channels, SLC13A5, SLC13A5 IN 1, SLC13A5IN1, SLC-13A5-IN-1, SLC13A5-IN-1, SodiumChannel, Sodium Channel, SCD, StearoylCoADesaturase(SCD), Stearoyl-CoA Desaturase, StearoylCoA Desaturase (SCD), StearoylCoADesaturase, recombinant hSLC3A5/14C-Citrate Uptake Assay, Uptake

Compound Identifiers

PubChem CID

134604225