SKPin C1

SKU: orb1303020

Description

SKPin C1 is a specific small molecule inhibitor that blocks Skp2-mediated p27 degradation. It is a valuable research tool for studying cell cycle regulation, proliferation, and oncogenesis in both cellular and animal models of cancer.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 432001-69-9
• MW: 465.3
• Purity: >98%
• Formula: C₁₈H₁₃BrN₂O₄S₂
• SMILES: OC(=O)COc1ccc(Br)cc1\C=C1/SC(=S)N(Cc2cccnc2)C1=O
• Target: Ubiquitin ligase
• Solubility: Soluble in DMSO (up to at least 10 mg/ml).

Bioactivity

• In Vitro:
  in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, Skp2, Skp2 Inhibitor C1, Skp-2 Inhibitor C1, SKPin C 1, SKPin C1, SKPin C-1, Inhibitor, inhibit, E1 Enzyme, E1 activating enzyme, E1Enzyme, E1/E2/E3 Enzyme, E3Enzyme, E3 ligating enzyme, E3 Enzyme, E2Enzyme, E2 conjugating enzyme, E2 Enzyme

Compound Identifiers

PubChem CID

5733396