SKLB4771

SKU: orb1306632

Description

SKLB4771 (FLT3-IN-1) is a potent and selective inhibitor of FMS-like tyrosine kinase 3 (FLT3). It is a valuable research tool for investigating FLT3-driven mechanisms in acute myeloid leukemia (AML), supporting both in vitro cellular assays and in vivo preclinical studies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1370256-78-2
• MW: 537.66
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₂₇N₇O₃S₂
• SMILES: Cc1ccc(NC(=O)Nc2nnc(Sc3ncnc4cc(OCCCN5CCOCC5)ccc34)s2)cc1
• Target: FLT,c-Kit,Apoptosis
• Solubility: DMSO:50 mg/mL (93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.72 mM)

Bioactivity

• Target IC50:
  FLT3:10 nM|FLT3 (ITD, MV4-11 cells):6 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

phosphorylation, selective, SKLB 4771, SKLB4771, SKLB-4771, SCFR, inhibit, FLT3, FLT3-​IN-​1, FLT3-IN-1, Fms like tyrosine kinase 3, Inhibitor, apoptosis induction, cell proliferation inhibition, c-Kit, Cluster of differentiation antigen 135, CD135, CD117

Compound Identifiers

PubChem CID

57412684