SKLB1002

SKU: orb1222802

Description

SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.

Key Properties

• CAS Number: 1225451-84-2
• MW: 320.39
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₂N₄O₂S₂
• SMILES: COc1c(OC)cc2c(Sc3nnc(C)s3)ncnc2c1
• Target: VEGFR2
• Solubility: DMSO : 5.625 mg/mL 17.56 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKLB1002 | SKLB 1002 | SKLB1002

Quick Database Links

Gene Symbol

VEGFR2