SKLB-23bb

SKU: orb1301451

Description

SKLB-23bb is a selective HDAC6 inhibitor with oral bioavailability and microtubule-disrupting properties. It is a valuable research tool for studying HDAC6 biology, cancer mechanisms, and for conducting both in vitro cellular assays and in vivo animal model experiments.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1815580-06-3
• MW: 396.44
• Purity: ≥98% (May vary between batches)
• Formula: C₂₁H₂₄N₄O₄
• SMILES: COc1ccc(cc1OCCCC(=O)NO)N(C)c1nc(C)nc2ccccc12
• Target: HDAC
• Solubility: DMSO:32 mg/mL (80.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.04 mM)

Bioactivity

• Target IC50:
  HDAC6:17 nM
• In Vivo:
  In vivo efficacy evaluations of colorectal HCT116, acute myelocytic leukemia MV4-11, and B cell lymphoma Romas xenografts, SKLB-23bb more effectively inhibited the tumor growth than SAHA even at a 4-fold reduced dose or ACY-1215 at the same dose. SKLB-23bb is a potent oral anticancer candidate for selective HDAC6 inhibitor.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Histone deacetylases, HDAC, HDAC6, Inhibitor, SKLB 23bb, SKLB23bb, SKLB-23bb

Compound Identifiers

PubChem CID

122550211