SKLB-163

SKU: orb1305259

Description

SKLB-163 is a small molecule that functions by downregulating RhoGDI, which leads to JNK-1 pathway activation and caspase-3 induction, while suppressing phosphorylated Akt and p44/42 MAPK. This mechanism supports its application in cancer research, particularly in studies of apoptosis and cell signaling in vitro.

Research Area

Cell Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 1255099-06-9
• MW: 405.92
• Purity: 99.23% (May vary between batches)
• Formula: C₁₈H₁₆ClN₃O₂S₂
• SMILES: S(CC(NCC1=CC=CC=C1)=O)C2=NC=3C(S2)=CC(NC(CCl)=O)=CC3
• Target: Rho,JNK,Akt,MAPK,Caspase,Apoptosis
• Solubility: DMSO:247.5 mg/mL (609.73 mM)

Bioactivity

• Target IC50:
  BxPC-3 cells:6.6 μM|A431 cells:4.4 μM|A375 cells:1.8 μM|A549 cells:4 μM|HCT116 cells:1.3 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p44/42 MAPK, SKLB 163, SKLB163, SKLB-163, RhoGDI, JNK1, caspase-3, Akt

Compound Identifiers

PubChem CID

51003475