SKLB-03220

SKU: orb3027378

Description

SKLB-03220 is an orally bioavailable covalent inhibitor targeting the histone methyltransferase EZH2, an established oncology drug target involved in epigenetic regulation. SKLB-03220 is structurally based on the clinically approved EZH2 inhibitor tazemetostat and demonstrates the ability to abolish epigenetic H3K27me3 marks, thereby altering chromatin state and transcriptional activity. SKLB-03220 represents a potent small-molecule tool for cancer epigenetics research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2852050-29-2
• MW: 556.71
• Purity: 97.02%
• Formula: C₃₃H₄₀N₄O₄
• SMILES: O=C(C=C)NC1=CC=C(C(=C1)C=2C=C(C(=O)NCC=3C(=O)NC(=CC3C)C)C(=C(C2)N(CC)C4CCOCC4)C)C
• Target: Histone Methyltransferase

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKLB03220, Sklb-03220

Quick Database Links

Gene Symbol

Histone Methyltransferase