SKLB-0124

SKU: orb3181103

Description

SKLB-0124 is a potent degrader of PRMT6, exhibiting DC50 values of 15.4 μM in HCC827 cells and 16.4 μM in MDA-MB-435 cells. It does not degrade PRMT1 or PRMT8. SKLB-0124 has an IC50 value of 1.6 μM for PRMT6. It induces proteasome-dependent degradation of PRMT6 and significantly inhibits cell proliferation. Additionally, SKLB-0124 effectively induces apoptosis and cell cycle arrest, making it suitable for research in lung cancer and breast cancer.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 3065966-31-3
• MW: 531.75
• Formula: C₃₂H₄₅N₅O₂
• SMILES: O=C(NC1=CC=C(C=C1)C=2C=NC=C(C2)CN(C)CCNC)CCCNC(=O)CC34CC5CC(CC(C5)C3)C4
• Target: Apoptosis,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Histone Methyltransferase