SKI V

SKU: orb1298915

Description

SKI V is a potent, non-lipid inhibitor of sphingosine kinase (SPHK; IC50 = 2 μM) and PI3K (IC50 = 6 μM). This dual activity induces apoptosis and confers antitumor properties, making it a valuable tool for studying cancer signaling pathways in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 24418-86-8
• MW: 254.24
• Purity: 99.62% (May vary between batches)
• Formula: C₁₅H₁₀O₄
• SMILES: Oc1ccc(\C=C2\Oc3ccccc3C2=O)cc1O
• Target: Apoptosis,S1P Receptor,PI3K
• Solubility: DMSO:2.55 mg/mL (10.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.93 mM)

Bioactivity

• Target IC50:
  PI3k (human):6 μM |ERK2:80 μM|GST-hSK:2 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

second, Phosphoinositide 3-kinase, PI3K, SKI V, S1PReceptor, S1P, S1P Receptor, sphingosine, Sphingosine kinase, SphK, Inhibitor, inhibit, noncompetitive, non-lipid, kinase, mitogenic, messenger, GST-hSK, Apoptosis, antitumor

Compound Identifiers

PubChem CID

21100709