SKI-178

SKU: orb1298446

Description

SKI-178 is a potent SphK1 inhibitor (IC50 0.1-1.8 µM) that triggers prolonged mitosis and intrinsic apoptosis. This effect is mediated by sustained CDK1 activity, which phosphorylates Bcl-2 and Bcl-xL while degrading Mcl-1. It serves as a valuable chemical probe for studying sphingolipid signaling, cell cycle arrest, and apoptosis in cancer research models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1259484-97-3
• MW: 394.42
• Purity: 99.20% (May vary between batches)
• Formula: C₂₁H₂₂N₄O₄
• SMILES: COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1
• Target: S1P Receptor,Apoptosis
• Solubility: DMSO:50 mg/mL (126.77 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (6.34 mM)

Bioactivity

• Target IC50:
  SPHK1:0.1-1.8 μM
• In Vitro:
  SKI-178 is a multi-targeted agent that functions both as an inhibitor of the SphKs as well as a disruptor of the microtubule network. SKI-178 induced apoptosis arises from a synergistic interaction of these two activities. SKI-178 is safe and effective in mouse models of AML, supporting its further development as a multi-targeted anti-cancer therapeutic agent.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

myeloid, multi-drug, inhibit, Inhibitor, leukemia, cell, drug, cytotoxic, cancer, Apoptosis, sensitive, S1P Receptor, S1PReceptor, resistant, SphK1, SphK2, SphK, Sphingosine kinase, SKI 178, SKI178, SKI-178

Compound Identifiers

PubChem CID

5342941