SKF-96365

SKU: orb1306231

Description

SKF-96365 hydrochloride

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 130495-35-1
• MW: 402.9
• Purity: >98%
• Formula: C₂₂H₂₆N₂O₃ ∙ HCl
• SMILES: Cl.COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).

Bioactivity

• In Vivo:
  SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo.
• In Vitro:
  SKF-96365 exhibits protective activity against MPP+ injury in PC12 cells and significantly inhibits apoptotic cell death in PC12 cells after MPP+ administration. SKF-96365 does not exert effects on necrotic cell death induced by MPP+ insult in PC12 cells. Because of its non-selective activity, SKF-96365 has been demonstrated to have effects on multiple other Ca2+ channels: it not only blocks high-voltage-activated (HVA) Ca2+ channels at typically utilized test concentrations, but also potently inhibits low-voltage -activated (LVA) T-type Ca2+ channels in HEK293 cells. The exact effect of SKF-96365 on intracellular calcium homeostasis might dependent on cell types and experimental models used.
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• Cell Research:
  To investigate whether SKF-96365 could protect PC12 cells from injury induced by MPP+ insult, cultured PC12 cells are pretreated with SKF-96365 in different concentrations (1 µM, 10 µM or 50 µM) 30 min before MPP+ addition. The cells viability is measured 24 h after MPP+ insult by using the cell proliferation reagent WST-1. (Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, KcsA, inhibit, interval, CalciumChannel, cancer, Calcium release-activated channels, Calcium Channel, Ca2+ release-activated Ca2+ channels, Autophagy, arrest, Apoptosis, anti-neoplastic, CRAC Channel, cell-cycle, colorectal, Potassium Channel, PotassiumChannel, QTc, SKF96365, SKF-96365, SKF96365 Hydrochloride, SKF96365 hydrochloride, SKF-96365 Hydrochloride, SKF 96365, SKF 96365 Hydrochloride, SKF 96365 hydrochloride, prolong, TRP, TRP Channel, TRPChannel, TRPV Channel, TRPVChannel, Transient receptor potential channels

Compound Identifiers

PubChem CID

104955