SK33

SKU: orb1309091

Description

SK33 is a potent, tissue-selective anti-androgen that suppresses androgen receptor (AR)-mediated transcriptional activity. It is a valuable research tool for studying AR function in prostate cancer and other androgen-dependent pathologies, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1928724-23-5
• MW: 500.31
• Purity: 99.66% (May vary between batches)
• Formula: C₂₀H₁₃F₉N₂O₃
• SMILES: CC(O)(COc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F
• Target: Androgen Receptor
• Solubility: DMSO:55 mg/mL (109.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4 mM)

Bioactivity

• Target IC50:
  LNCaPAR+ cells:0.2 μM
• In Vivo:
  AR transcriptional activity inhibited by SK33 after 50 mg/kg treatment for 24 hours.
• In Vitro:
  SK33 has a significantly potent activity (IC50:0.2 μM) in LNCaPAR+ cells. SK33 decreases cells enter S-phase in LNCaP cells. In LNCaP/BicR cells, increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth(IC50 : 5 μM for SK33).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

prostate, tissue, SK 33, SK33, SK-33, cancer, Androgen Receptor, AndrogenReceptor, analogues, androgen, cells, LNCaP, inhibit, PC3, Inhibitor

Compound Identifiers

PubChem CID

127043517