SK2188

SKU: orb3135025

Description

SK2188 is a potent and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM). SK2188 induces DNA damage and triggers apoptosis, indirectly degrades MYCN, thereby inhibiting tumor cell proliferation, providing new insights for research on MYCN-amplified neuroblastoma.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 3038446-94-2
• MW: 893.38
• Formula: C₄₃H₄₆ClFN₆O₁₀S
• SMILES: C([C@@]1(C(NCCOCCOCCOCCOC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)CC[C@@H](OC5=C(F)C(Cl)=CC=C5)CC1)C=6N=C(NC7=NC=CS7)C=CC6
• Target: Apoptosis,Aurora Kinase,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Aurora Kinase,PROTACs