SK1-I hydrochloride

SKU: orb1689232

Description

SK1-I hydrochloride is the salt form of the selective sphingosine kinase 1 (SphK1) inhibitor SK1-I (BML-258). This compound exhibits anti-leukemic activity by inhibiting tumor cell growth and inducing apoptosis in vitro, and has been utilized in research exploring cancer therapeutics and sphingolipid signaling pathways.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2366222-05-9
• MW: 313.86
• Purity: 99.80% (May vary between batches)
• Formula: C₁₇H₂₈ClNO₂
• SMILES: C(=C/[C@@H]([C@@H](CO)NC)O)\C1=CC=C(CCCCC)C=C1.Cl
• Target: S1P Receptor

Bioactivity

• In Vivo:
  In the C57BL/6 male mouse model, pretreatment with SK1-I hydrochloride (intraperitoneal injection, 75mg/kg, a single dose administered 24 hours before baseline mean arterial pressure measurement) showed a significant hypotensive effect, significantly reducing the baseline mean arterial pressure (MAP) .
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• In Vitro:
  The effect of SK1-I hydrochloride on cancer cell growth, survival, and apoptosis is closely related to the TP53 status. Treatment of HCT116 cells with a defective TP53 mutation and normal HCT116 cells with SK1-I hydrochloride (0-10μM) for 24 hours revealed that the growth and survival rate of normal HCT116 cells decreased significantly. In protein blot analysis, after treating both cell types with SK1-I hydrochloride (0-20μM) for 12 hours, it was found that CASP3 cleavage was increased in normal HCT116 cells, making them more prone to apoptosis .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BML258 hydrochloride, BML-258 hydrochloride

Compound Identifiers

PubChem CID

49793059