SJF 1521

SKU: orb1693911

Description

SJF 1521 is a PROTAC-based small molecule that induces selective degradation of EGFR without affecting HER2. It serves as a valuable chemical probe for studying EGFR-dependent signaling and oncology research in both cellular and animal models.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2230821-40-4
• MW: 1074.65
• Purity: 99.20% (May vary between batches)
• Formula: C₅₇H₆₁ClFN₇O₉S
• SMILES: N(C=1C2=C(C=CC(=C2)C3=CC=C(OCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C=C3)N=CN1)C7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7
• Target: PROTACs,EGFR
• Solubility: DMSO:80 mg/mL (74.44 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EGFR, PROTAC, SJF 1521, SJF1521, SJF-1521

Compound Identifiers

PubChem CID

135157094