SJB2-043

SKU: orb1299600

Description

SJB2-043 is a potent small molecule inhibitor of the USP1-UAF1 deubiquitinase complex, exhibiting an IC50 of 544 nM. It is a valuable research tool for studying DNA damage repair pathways and has been utilized in both cellular and in vivo models to investigate cancer biology and chemotherapy resistance.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 63388-44-3
• MW: 275.26
• Purity: 99.35% (May vary between batches)
• Formula: C₁₇H₉NO₃
• SMILES: O=C1c2nc(oc2C(=O)c2ccccc12)-c1ccccc1
• Target: DUB
• Solubility: DMSO:3.33 mg/mL (12.1 mM)

Bioactivity

• Target IC50:
  USP1/UAF1:544 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DUBs, Deubiquitinase, Inhibitor, inhibit, USP1-UAF1, SJB2-043, SJB2 043, SJB2043, SJB-2-043

Compound Identifiers

PubChem CID

509070