SJ-172550

SKU: orb1307742

Description

SJ-172550 is a potent and selective small-molecule inhibitor of MDMX, exhibiting an EC50 of 5 μM. This compound is a valuable research tool for studying p53-MDMX interactions in cancer biology, applicable in both in vitro biochemical assays and cellular studies to explore tumor suppression pathways.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 431979-47-4
• MW: 428.87
• Purity: 99.87% (May vary between batches)
• Formula: C₂₂H₂₁ClN₂O₅
• SMILES: CCOc1cc(\C=C2/C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC
• Target: E1/E2/E3 Enzyme,Mdm2,MDM-2/p53
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.66 mM);DMSO:33.33 mg/mL (77.72 mM)

Bioactivity

• Target IC50:
  MDMX:5 μM
• In Vitro:
  SJ-172550 interacts with the p53-binding pocket of MDMX, effectively displacing p53 and reversibly binding to MDMX, resulting in the death of retinoblastoma cells with amplified MDMX expression. This compound establishes a covalent, yet reversible, complex with MDMX, which prohibits MDMX from binding to p53. The efficacy of SJ-172550 is enhanced when used in conjunction with the MDM2 inhibitor, nutlin-3a. The stability of the SJ-172550/MDMX complex is dependent on several factors, such as the media's reducing potential and the presence of aggregates.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3Enzyme, E3 ligating enzyme, E3 Enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E1Enzyme, E1/E2/E3 Enzyme, E1 activating enzyme, E1 Enzyme, inhibit, MDM-2/p53, MDMX, Inhibitor, SJ172550, SJ-172550, SJ 172550, Ubiquitin activating enzyme, Ubiquitin ligase, Ubiquitin conjugating enzyme

Compound Identifiers

PubChem CID

1317464