Sitagliptin phosphate monohydrate

SKU: orb1741539

Description

Sitagliptin phosphate monohydrate

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 654671-77-9
• MW: 523.33
• Purity: 99.98%
• Formula: C₁₆H₁₅F₆N₅O·H₃PO₄·H₂O
• SMILES: OP(O)(O)=O.N[C@H](CC1=C(C=C(C(F)=C1)F)F)CC(N2CCN3C(C2)=NN=C3C(F)(F)F)=O.O
• Target: Autophagy,DPP-4,Proteasome
• Solubility: DMSO:93 mg/mL (177.71 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:38 mg/mL (72.61 mM)

Bioactivity

• Target IC50:
  DPP4:19 nM
• In Vitro:
  The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, DPP-4, DPP4, Dipeptidyl Peptidase, MK0431, MK-0431, MK0431 Phosphate, MK-0431 phosphate monohydrate, MK 0431, MK 0431 Phosphate

Compound Identifiers

PubChem CID

11591741