Sitagliptin phosphate monohydrate

SKU: orb1741539

Description

Sitagliptin phosphate monohydrate

Research Area

Cell Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 654671-77-9
• MW: 537.3076
• Purity: 99.98% (May vary between batches)
• Formula: C₁₆H₁₈F₆N₅O₇P
• SMILES: O.OP(O)(O)=O.N[C@@H](CC(=O)N1CCN2C(C1)=NN=C2C(F)(F)F)C(=O)C1=C(F)C=C(F)C(F)=C1
• Target: DPP-4,Autophagy
• Solubility: DMSO:93 mg/mL (177.71 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:38 mg/mL (72.61 mM)

Bioactivity

• Target IC50:
  DPP4:19 nM
• In Vitro:
  The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, DPP-4, DPP4, Dipeptidyl Peptidase, MK0431, MK-0431, MK0431 Phosphate, MK-0431 phosphate monohydrate, MK 0431, MK 0431 Phosphate

Compound Identifiers

PubChem CID

11591741