SIRT7 inhibitor 97491

SKU: orb1303559

Description

The small molecule inhibitor 97491 selectively targets SIRT7 (IC50 = 325 nM), functioning as a specific HDAC inhibitor. It induces apoptosis via caspase activation and is a valuable research tool for studying SIRT7's role in cancer biology and cellular processes in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Key Properties

• CAS Number: 1807758-81-1
• MW: 285.73
• Purity: 99.79% (May vary between batches)
• Formula: C₁₅H₁₂ClN₃O
• SMILES: Nc1cccc(Nc2ncc(o2)-c2ccc(Cl)cc2)c1
• Target: Sirtuin
• Solubility: DMSO:250 mg/mL (874.95 mM);10% DMSO+90% Corn Oil:5 mg/mL (17.5 mM)

Bioactivity

• Target IC50:
  SIRT7:325 nM
• In Vivo:
  The SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) effectively suppresses tumor growth in xenograft mice. Utilizing Balb/c nude mice (18-20 g; 6-8 weeks old) implanted with MES-SA cells, the dosage administered was 2 mg/kg via intraperitoneal injection over a three-week period, excluding weekends. The outcome was a significant inhibition of cancer growth in vivo.
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• In Vitro:
  SIRT7 inhibitor 97491 (1-10 μM) effectively reduces the proliferation of human uterine sarcoma MES-SA cells by over 50% at 5 and 10 μM after 72 hours, without cytotoxic effects on HEK293 human embryonic kidney cells after 24 hours of exposure, indicating selective action.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

deacetylase, Inhibitor, p53 K373/382, inhibit, Apoptosis, Sirtuin, SIRT7, SIRT7 inhibitor 97491, SIRT-7 inhibitor 97491, tumor

Compound Identifiers

PubChem CID

146018038