SIRT6-IN-4

SKU: orb2945550

Description

SIRT6-IN-4 (Compound 10d) is a selective SIRT6 inhibitor (IC50 = 5.68 µM) with anti-cancer properties. It inhibits proliferation, migration, and invasion of MCF-7 cells in vitro, induces G2/M arrest and apoptosis, and demonstrates in vivo antitumor activity in mouse models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• MW: 451.907
• Formula: C₂₆H₁₈ClN₅O
• SMILES: C1=CC=NC(=C1)CNC(=O)C2=NC=C3C(=C2)C4=C(N3CC5=CC=C(C=C5)C#N)C=CC(=C4)Cl
• Target: Sirtuin,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676972