SIRT2-IN-9

SKU: orb1687529

Description

SIRT2-IN-9 is a potent and selective SIRT2 inhibitor (IC50 = 1.3 µM) that suppresses the proliferation of MCF-7 breast cancer cells in vitro. This compound serves as a valuable chemical probe for investigating SIRT2's role in oncology and related cellular processes.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 522650-91-5
• MW: 438.57
• Purity: 97.60% (May vary between batches)
• Formula: C₂₁H₂₂N₆OS₂
• SMILES: CCCn1c2ccccc2c2nnc(SCC(=O)Nc3nc4CCCCc4s3)nc12
• Target: Sirtuin
• Solubility: DMSO:4 mg/mL (9.12 mM)

Bioactivity

• Target IC50:
  SIRT2:1.3 μM|SIRT3:＞300 μM|SIRT1:＞300 μM
• In Vitro:
  SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SIRT2 (IC50=1.3 μM) while also inhibiting SIRT1 and SIRT3 (IC50s >300 μM). Additionally, SIRT2-IN-9 (0-50 μM; 72 h) affects the cell viability and dose-dependently inhibits the proliferation of MCF-7 breast cancer cells. SIRT2-IN-9 (0-50 μM; 6 h) also impacts the acetylation of α-tubulin protein.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SIRT2

Compound Identifiers

PubChem CID

2938199