Sirt2-IN-1

SKU: orb1708521

Description

Sirt2-IN-1 is a potent and selective sirtuin 2 (SIRT2) inhibitor with an IC50 of 163 nM. This compound is a valuable chemical probe for investigating the role of SIRT2 in vitro and in vivo, with applications in research areas such as neurodegeneration, cancer, and metabolic disorders.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1862238-00-3
• MW: 557.69
• Purity: 99.05% (May vary between batches)
• Formula: C₂₈H₂₇N₇O₂S₂
• SMILES: Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(Cc5ccccc5)nn4)c3)s2)n1
• Target: Sirtuin
• Solubility: DMSO:135 mg/mL (242.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.17 mM)

Bioactivity

• Target IC50:
  SIRT2:163 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SIRT2, Sirt2-IN-1, Sirt-2-IN-1, Sirt2 IN 1, Sirt2IN1

Compound Identifiers

PubChem CID

112499922