Sirt1/2-IN-3

SKU: orb2277853

Description

Sirt1/2-IN-3 is a dual SIRT1/2 inhibitor (IC50: 1.4 μM and 2.0 μM) that increases acetylation of p53 and α-tubulin, blocking deacetylation. It induces apoptosis and shows antiproliferative activity in human leukemia cell lines in vitro, supporting its use in oncology and epigenetics research.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 301313-42-8
• MW: 363.82
• Formula: C₁₇H₁₄ClNO₄S
• SMILES: COC1=CC=C(C=C1)S(=O)(=O)NC1=C2C=CC=CC2=C(O)C(Cl)=C1
• Target: Sirtuin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

1183798