SirReal1-O-propargyl

SKU: orb1987782

Description

SirReal1-O-propargyl is a potent and selective Sirtuin 2 (SIRT2) inhibitor with an IC50 of 2.4 µM. It serves as a versatile PROTAC ligand, and its propargyl moiety facilitates click chemistry conjugation for probe development. This compound is a valuable tool for studying SIRT2 biology in cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1862237-99-7
• MW: 424.54
• Formula: C₂₁H₂₀N₄O₂S₂
• SMILES: O=C(NC1=NC=C(S1)CC=2C=CC=C(OCC#C)C2)CSC=3N=C(C=C(N3)C)C
• Target: Others

Bioactivity

• Target IC50:
  SIRT2:2.4 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IC50: 2.4 μM (Sirt2), SirReal1-O-propargyl, SirReal-1-O-propargyl, SirReal1 O propargyl, SirReal1Opropargyl, PROTAC Sirt2-binding moiety 1

Compound Identifiers

PubChem CID

138319670