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Siramesine
Catalog Number: orb1689964
| Catalog Number | orb1689964 |
|---|---|
| Category | Small Molecules |
| Description | Siramesine |
| Purity | 98.00% |
| MW | 454.58 |
| Biological Activity | Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost |
| CAS Number | [147817-50-3] |
| Formula | C30H31FN2O |
| SMILES | C(CCCC=1C=2C(N(C1)C3=CC=C(F)C=C3)=CC=CC2)N4CCC5(C=6C(CO5)=CC=CC6)CC4 |
| Storage | -20°C |
| Note | For research use only |
Siramesine [orb1223287]
> 98% (HPLC)
147817-50-3
454.6
C30H31FN2O
1 g, 500 mg, 200 mg, 100 mg, 5 mg, 10 mg, 50 mg, 25 mgLu-28-179 [orb1225611]
> 98%(HPLC)
224177-60-0
491
C30H32ClFN2O
2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg, 200 mgSiramesine hydrochloride [orb1307267]
99.75%
[224177-60-0]
491.04
C30H32ClFN2O
100 mg, 50 mg, 10 mg, 5 mg, 2 mg, 1 mg, 25 mg, 1 ml x 10 mM (in DMSO)
