Siramesine

• Catalog Number: orb1689964
• Category: Small Molecules
• Description: Siramesine
• CAS Number: 147817-50-3
• Purity: 98%
• MW: 454.58
• SMILES: C(CCCC=1C=2C(N(C1)C3=CC=C(F)C=C3)=CC=CC2)N4CCC5(C=6C(CO5)=CC=CC6)CC4
• Formula: C₃₀H₃₁FN₂O
• Biological Activity: Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.