Sinomenine

SKU: orb1305106

Description

Sinomenine (Kukoline) is an alkaloid derived from Sinomenium acutum, studied for its potential in rheumatism and arthritis research. In vitro and in vivo studies indicate it possesses anti-inflammatory and immunomodulatory properties relevant to autoimmune disease models.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 115-53-7
• MW: 329.39
• Purity: 99.89% (May vary between batches)
• Formula: C₁₉H₂₃NO₄
• SMILES: COC1=C[C@@H]2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O
• Target: Opioid Receptor,Autophagy,NF-κB,Apoptosis
• Solubility: DMSO:148 mg/mL (449.32 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.14 mM);H2O:10 mg/mL (30.36 mM)

Bioactivity

• In Vivo:
  Sinomenine is currently believed to primarily mediate its effects through the release of histamine and may also exert anti-rheumatic properties by mechanisms such as inhibiting the synthesis of prostaglandins, leukotrienes, and nitric oxide.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cucoline, Autophagy, Apoptosis, Inhibitor, inhibit, Kukoline, NF-kB, NFκB, NFkB, NF-κB, Nuclear factor-kappaB, Nuclear factor-κB, Opioid Receptor, OpioidReceptor, Sinomenine

Compound Identifiers

PubChem CID

5459308