Sincalide ammonium

SKU: orb1984051

Description

Sincalide ammonium (CCK-8 ammonium) is a bioactive peptide analog of cholecystokinin that stimulates gallbladder contraction and bile secretion for diagnostic imaging. It is widely used in research applications involving gastrointestinal physiology, both in vivo and in vitro, to study biliary and pancreatic function.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 70706-98-8
• MW: 1160.3
• Purity: 98.46% (May vary between batches)
• Formula: C₄₉H₆₅N₁₁O₁₆S₃
• SMILES: N.CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
• Target: Cholecystokinin Receptor,PI3K,Akt,Apoptosis
• Solubility: H2O:30 mg/mL (25.86 mM)

Bioactivity

• In Vivo:
  In a rat model of myocardial infarction (MI), Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, alleviates fibrosis in the noninfarcted regions. Furthermore, it delays left ventricular remodeling and the progression of heart failure in the MI rat model.
• In Vitro:
  Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, functions as a novel cardiovascular hormone with a significant inhibitory effect on myocardial fibrosis in noninfarcted areas. It also exhibits a positive role in combating inflammation, apoptosis, and collagen deposition. In the context of H9c2 cardiomyoblasts, CCK‐8 (ammonium) protects cells from Ang II-induced apoptosis, partly through the activation of the CCK1 receptor and the phosphatidylinositol‐3 kinase/protein kinase B (PI3K/Akt) signaling pathway.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cholecystokinin octapeptide ammonium, CCK, CCK-8 ammonium, Sincalide ammonium, SQ19844 ammonium

Compound Identifiers

PubChem CID

145712427