Sinapyl alcohol

SKU: orb1297147

Description

This technical grade small molecule is naturally sourced from Magnolia sieboldii. It is utilized in biochemical research for in vitro studies investigating natural product chemistry and potential bioactive properties, serving as a reference standard or experimental compound.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 537-33-7
• MW: 210.23
• Purity: 97.28% (May vary between batches)
• Formula: C₁₁H₁₄O₄
• SMILES: COc1cc(\C=C\CO)cc(OC)c1O
• Target: COX|||NOS
• Solubility: DMSO:125 mg/mL (594.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.51 mM)

Bioactivity

• In Vivo:
  Sinapyl alcohol (20,30mg/kg/day, p.o.) inhibited increased vascular permeability by acetic acid in mice and reduced acute paw edema by carrageenan in rats more so tan syringin.
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• In Vitro:
  Sinapyl alcohol more potently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor (TNF)-α production by macrophages than syringin. Consistent wih thse observations, the expression levels of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 was reduced by sinapyl alcohol in a concentration-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

iNOS, COX-2, COX-2,iNOS, Sinapyl alcohol

Compound Identifiers

PubChem CID

5280507